Endocrine Abstracts

Introduction: Pharmacological treatments are still not ideal in ACTH-microadenomas and transnasal-trans-sphenoidal surgery (TSS) is first choice in the treatment of Cushing’s disease (CD). The question is how can a nearly 100% remission rate be achieved with minimally invasive diagnostic testing and TSS. In the discussion of the main lecture from an expert from the USA in ECE13, it became clear that in many European centres, like ours, the procedures are less invasive. Th...

Stereotactic hypothalamotomy in the treatment of morbid sexual deviation was first performed by Prof. Dr. Fritz Roeder 1966 in Univ. Göttingen and installed in University Hamburg-Eppendorf (UKE) by Neuropathologist Dr. Dieter Müller (DM) in the late 1970s. Dr. Dieter Lüdecke (DKL) agreed with Prof. Herrmann, Director of Neurosurgery, to give the Professor position to DM to join the Unit. It was known that the sex behaviour centre in the ventromedial nucleus of C...

Introduction: Pharmacological treatments are available for all functioning pituitary adenomas, but found to be only ideal in prolactinomas. Therefore, at least in ACTH- and GH-microadenomas we have to strive to achieve 100% remission with transnasal surgery. Our question is, which combination of an increasing arsenal of pre- and peri-operative methods will bring the pituitary surgeons to this result without increasing complications.Materials and methods:...

Introduction: Trans-sphenoidal surgery (TSS) with minimally invasive techniques is the first choice in the treatment of paediatric Cushing’s disease (CD). The question is how can high remission rates be achieved with less invasive investigations and TSS. The developments in our centre treating 100 pediatric Cushing patients with long-term follow-up may add some helpful ideas.Material and methods: Data from our first series 1 (n=55) will be ...

Introduction: Generously supported by IPSEN)-->Pituitary infarction is rare in the paediatric age. In adolescents and adults it is often secondary to haemorrhage into an underlying lesion such as pituitary adenoma or cyst. Lymphocytic hypophysitis is rare in children and usually peri-tumoral due to germinoma, craniopharyngioma or Rathke’s cyst and often associated with hypopituitarism and diabetes insipidus.<p class="abstext...

Background: Immune responses to self-peptides should not generally occur. However, four of 12 autoimmune Addison’s disease (AAD) patients developed adverse reactions immediately after synacthen injections, following repeated subcutaneous synacthen injections during a clinical trial (RoSA study). We wondered if these adverse effects were due to the production of anti-synacthen (ACTH1–24) antibodies.Methods: We evaluated the presence o...

Objective: The origin of idiopathic isolated secondary adrenal insufficiency (IISAI) is uncertain, however autoimmunity seems to be the most probable cause. Within last eight years the initial number of about 100 such cases, increased in our registry by 250%. We searched for features of autoimmune diseases in our group of patients to prove autoimmune etiology in a majority of these patients.Materials and methods: The material consisted of 260 patients wi...

Studies on autoimmune Addison’s disease (AD) have a long tradition, while knowledge on idiopathic isolated secondary adrenal insufficiency (SAI), which also seems to be caused by autoimmunity, is not so popular. Our presentation aimed at comparing two groups of patients: 1) 238 patients with AD (183 women, F/M=4.3), aged 8–61 years at time of diagnosis and 2) 301 patients with SAI (269 women, F/M=8.4), aged 17–87 years at time of diagnosis. Maximum time of durat...